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DOSSAGE Oral Menopausal hormone replacement therapy Adult: In menopausal women: 10-20 mcg daily in conjunction with a progestogen in women with uterus. Oral Female hypogonadism Adult: 10-50 mcg daily in a cyclical regimen. Oral Palliative treatment of breast carcinoma Adult: In postmenopausal women: 0.1-1 mg tid. Oral Palliative treatment of prostatic carcinoma Adult: 0.15-3 mg daily. Oral As part of combined oral contraceptive Adult: As the oestrogenic component of combined oral contraceptive: 20-40 mcg/day. Estrogens should not be used in individuals with any of the following conditions: 1. Undiagnosed abnormal genital bleeding. 2. Known, suspected, or history of cancer of the breast. 3. Known or suspected estrogen-dependent neoplasia 4. Active deep vein thrombosis, pulmonary embolism, or history of these conditions. 5. Active or recent (e.g., within the past year) arterial thromboembolic disease (e.g., stroke, myocardial infarction). 6. Liver dysfunction or disease. 7. EstroGel therapy should not be used in patients with known hypersensitivity to its ingredients. 8. Known or suspected pregnancy. There is no indication for EstroGel in pregnancy. There appears to be little or no increased risk of birth defects in children born to women who have used estrogens and progestins from oral contraceptives inadvertently during early pregnancy.