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Who this guidance is for: use by federal, state, and local public health officials, respiratory protection program managers, occupational health service leaders, infection prevention and control program leaders, and other leaders in healthcare settings who are responsible for developing and implementing policies and procedures for preventing pathogen transmission in healthcare settings. Purpose: Considerations for the use of powered air-purifying respirators (PAPRs) to provide respiratory protection to healthcare practitioners (HCP) as a component of a formally developed and implemented written respiratory protection program. It addresses conventional, contingency, and crisis surge PAPR use and maintenance practices. This interim guidance is based on what is currently known about the transmission and severity of coronavirus disease 2019 (COVID-19). For concerns you may chat and message us first.