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Benefits of MSM Supplements Methylsulfonylmethane, more commonly known as MSM, is a popular dietary supplement used to treat a wide array of symptoms and conditions. Here are 8 science-backed health benefits of MSM. 1.Studies have shown that MSM is effective in reducing joint pain, stiffness and swelling. In doing so, it can improve your quality of life. 2. Has Anti-Inflammatory Effects, Such as Increasing Glutathione Levels The anti-inflammatory properties of MSM are well documented by scientific research. MSM may reduce the release of molecules associated with inflammation, such as TNF-ɑ and IL-6, as well as boost levels of the powerful antioxidant glutathione. 3. Can Speed Recovery After Exercise by Reducing Muscle Damage and Stress During exhaustive exercise, muscle damage occurs and oxidative stress increases (8Trusted Source). MSM may help reduce pain, muscle damage and oxidative stress after intense exercise, helping you recover more quickly. 4. Helps Alleviate Arthritis Symptoms by Reducing Pain and Stiffness Arthritis is a common inflammatory condition that causes pain, stiffness and a reduced range of motion in your joints. MSM supplements have been shown to help reduce pain and stiffness in people with arthritis. They may also help improve physical function. 5. MSM may help reduce allergy-related symptoms — including coughing, shortness of breath, congestion, sneezing and fatigue — by reducing inflammation. 6. Can Boost Immunity and Help You Stay Healthy Your immune system is a specialized network of tissues, cells and organs that protects your body against illness and disease. MSM may help boost your immune system by reducing inflammation and increasing glutathione levels. 7. Could Improve Skin Health by Strengthening Keratin Keratin is a protein that acts as the main structural component in your hair, skin and nails. MSM may improve skin health by strengthening keratin and reducing inflammation. It could even help reduce symptoms of certain skin conditions, as well. 8. May Have Cancer-Fighting Properties One of the newest areas of research involving MSM is studying its effectiveness in fighting cancer cells. Although the research is limited, the results have been promising so far. Research has shown that MSM exhibits cancer-fighting properties in test-tube and animal studies, but more research is needed.