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What Makes Hair Botox Different from Brazilian Keratin Treatment? While both treatments will give you similar results, Hair Botox and keratin treatment are actually quite distinct from one another. Things they have in common: They both create a smoothing effect, eliminate frizz, add shine, and help significantly reduce styling time. Differences: The biggest difference between them is that Hair Botox products don’t contain formaldehyde and other harsh chemicals that you can find in traditional keratin treatment products. Other differences include that Hair Botox is a deep conditioning treatment, which works to restore the natural beauty of damaged hair, while keratin treatment is intended primarily as a hair straightening method that is not recommended for extremely damaged hair.