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Again TO the development of technology very quickly, human being faced with two things, namely wellbeing and weakness in award to humanity. Mi book exposes ethical rational principles that can be used when humanity is at risk, both in health service and in daily life In this second edition, many data and topics updated and very importantly diskussed. Concrete issues concerning human beings, such as organ donors, medical actions, participation in research, also euthentication are diskussed with human dignity perspective and human rights. this book wants to affirm that in research action, human being placed as the center and not the human rights Victim of science and technology. This book needs to be read, not just by doctors, researchers, and medical officers, but especially by society who often exist in positions or subjects of research.