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Author: Kuswandi Isbn:978-602-386-336-5 First Print, July 2019 174 pages thick Size 15.5 cm x 23 cm Antibiotic resistance has become a complex global public health challenge, and no simple strategy has been enough to meet the appearance and spread of infectious organisms that become resistant to available antimicrobial medicine. The development of antibiotic resistance is a natural phenomenon in microorganisms and accelerated by selective pressure given by the use and misuse of antimicrobial agents in humans and animals so that antibiotics only kill sensitive bacteria populations on sufferers and microorganisms that will be Develops with rapids. Other factors that play a role on the presence of resistance microorganisms are the presence of spreading / displacement in other parts of the body to the hands of healthcare officers, to the environment around patients, other patients / visitors family, as well as society. The lack of new antimicrobial agents today to replace the antimicrobial agents that have already ineffectively added urgency to the need to protect the efficiency of existing medicines. The book is intended as a guide to healthcare practitioners and health students in understanding antibiotic resistance. By understanding consideration factors in the use of antibiotics, the use principle of antibiotics for empyrisal and definitive therapy, and resistance mechanism from each antibiotic, is expected to be expected health practitioners in particular and health field students in general can understand the use of antibiotics that Rational to avoid the occurrence of antibiotic resistance. The book provides knowledge for healthcare practitioners and students of health fields regarding the principles in antibiotic therapy, general picture of antibiotic resistance, and antibiotic resistance of each group. In Chapter 1 exposed regarding consideration factors in the use of antibiotics, empyris therapy and antibiotic definitive, antibiotic use principle for surgical profilactions, use of combination antibiotics, general antibiotic use, and antibiotic use in hospitals. In Chapter 2 is exposed regarding general antibiotic resistance. Subsequently, in Chapter 3 to Chapter 9 consecutively exposed regarding sulfonamide and trimethopride group antibiotic resistance, beta-lactic, glycoptide, aminoglycoside, quinolon, and etc., as well as antibiotics for tuberculosis therapy. Chapter 10 exposes regarding the horizontal distribution mechanism of antibiotic resistance in the microbiobial, while in the last chapter, namely Chapter 11, is revealed regarding antibiotic resistance control strategy.